Your First Rejuran Treatment: An Honest, Step-by-Step Guide to What Actually Happens

Let's be real.

No matter how much research you've done, walking into a clinic for your first Rejuran treatment comes with a few questions you haven't quite managed to Google away.

Will it hurt? What are those bumps? Am I going to walk out looking like I lost a mild argument with a cactus?

Valid questions, all of them. Here's exactly what happens — before, during, and after — so you can walk in knowing what to expect, and walk out knowing your skin is already getting to work.

Before You Arrive: The Consultation

Every Rejuran journey starts with a consultation — and if a clinic skips this step, that's your cue to leave.

During the consultation, your practitioner will assess your skin, determine whether Rejuran is suitable for you, and choose the most appropriate formulation — Classic, Eye, or Scar — based on your specific concerns.

This is also your chance to ask every question you've been holding onto. How many sessions will I need? What results can I realistically expect? What should I avoid beforehand?

A good practitioner won't rush this part. At Lumina, we treat the consultation as the most important part of the process — because a treatment that's right for your skin will always outperform one that's just popular.

A few things to do before your appointment:

• Avoid blood-thinning supplements like fish oil, vitamin E, and aspirin for at least a week beforehand if possible — these increase bruising risk
• Come with clean skin — no heavy makeup
• Stay well hydrated in the days leading up to your appointment

Step 1: Skin Cleanse

You arrive. You sit down. First things first — your skin is thoroughly cleansed to reduce infection risk.

Simple, but non-negotiable. Clean skin before any injection is basic clinical hygiene. If you've worn makeup, it comes off now.

Step 2: Numbing Cream

This is the part that makes first-timers exhale.

A topical numbing cream is applied across the treatment area and left to work for around 20 to 30 minutes. By the time the actual injections begin, most people feel very little — some describe a mild pressure, others barely notice anything at all.

The bumps afterwards consistently look more alarming than they feel. Worth remembering.

Step 3: The Treatment

After the numbing cream has taken effect, the treatment begins. Rejuran is administered via microinjections, carefully placed across the treatment area to maximise absorption and stimulate collagen production at the right depth.

The whole process typically takes 30 to 45 minutes.

You'll notice small raised bumps appearing as the treatment progresses — this is completely normal and exactly what's supposed to happen. The PDRN solution sits just beneath the skin surface, where it gets absorbed and begins activating your skin's repair response.

Step 4: Cryo Cooling

The injections are done. But your skin has just been through a lot of tiny punctures in quick succession — and it knows it.

This is where cryo cooling comes in. A controlled cold therapy is applied across the treated area to calm immediate redness, reduce swelling, and soothe any residual discomfort from the injections.

Think of it as your skin's version of an ice pack after a workout — except significantly more clinical, and considerably less soggy.

Step 5: Rejuran Soothing Mask + LED Light Therapy

Next, a Rejuran soothing mask is applied — and while it works, LED light therapy runs simultaneously.

The mask delivers calming and repairing actives directly to skin that's just been primed to absorb them. Post-injection skin is in active uptake mode, which means what you apply immediately after matters more than at any other time.

The LED works in the same direction as the Rejuran itself, just from a different angle — supporting collagen stimulation, accelerating the skin's natural healing response, and calming redness and inflammation.

The result? You leave looking noticeably more settled than you might expect after a treatment involving needles.

It also feels genuinely lovely. We won't pretend that's not part of the appeal.

Step 6: Sunscreen

Last step before you walk out the door — sunscreen.

SPF 50+ is applied to the treated area. This isn't optional courtesy — it's clinical necessity. Freshly treated skin is temporarily more vulnerable to UV damage, and in Sydney, that's not a risk worth taking even on a cloudy day.

This also sets the tone for what comes next: sunscreen every single morning, no exceptions, for the weeks that follow.

The Days That Follow

The bumps settle. The redness fades. And then — quietly, gradually — something starts to shift.

The bio-stimulator effect continues working for months after treatment, with improvements in collagen production and tissue regeneration becoming visible from week 2 to 3. More significant improvements — refined pores, reduced scarring, firmer skin — build over subsequent sessions.

Most people notice their skin feeling more hydrated and resilient first. The texture improvements and fine line reduction follow over the coming weeks. It's not dramatic. It's the kind of change where people ask if you've been sleeping better or drinking more water.

Which, honestly, is the best kind of compliment.

How Many Sessions Will You Need?

For the best results, Rejuran is typically done as a course of three sessions spaced two to four weeks apart, followed by maintenance treatments every six months.

Your first session sets the foundation. The second builds on it. By the third, most people see the results they came in for.

Frequently Asked Questions

Is Rejuran painful? Most people describe mild pressure rather than pain. The numbing cream does most of the heavy lifting. The bumps afterwards look worse than they feel — which is either reassuring or deeply ironic, depending on your perspective.

How long does a session take? Allow around 60 to 90 minutes for your first visit including consultation, numbing time, treatment, and the post-care steps. The actual injections take 30 to 45 minutes.

Can I go back to work the same day? Honestly — we'd advise against it. The bumps and redness can last longer than a few hours for some people, and in some cases may still be visible the following day. If your job involves facing people, cameras, or anything where your skin will be on show, give yourself at least 2 days of buffer. Plan your treatment for a Thursday or Friday and let the weekend do its job.

When will I see results? Some people notice improved hydration within the first week. Visible improvements in texture and fine lines typically appear from weeks 2 to 3, continuing to build over subsequent sessions.

Do I need to do anything special beforehand? Keep it simple. Hydrate well, avoid blood thinners if possible, and arrive with clean skin. That's really it.

Ready to Book Your First Session?

The first step is always the hardest — mostly because you don't know what to expect. Now you do.

At Lumina Skin Lab in Hornsby, we keep first appointments unhurried. You'll meet the person doing your treatment before anything else happens, and you'll leave with a clear picture of what your skin journey looks like from here.

👉 Book Your First Rejuran Consultation 👉 Read Our Rejuran Aftercare Guide